Determination of flunixin by sensitized terbium fluorescence in the presence of surfactant micelles |
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Authors: | T. D. Smirnova S. N. Shtykov E. A. Zhelobitskaya M. I. Safarova |
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Affiliation: | 1.Institute of Chemistry,Chernyshevsky Saratov National Research University,Saratov,Russia;2.OOO NITA-FARM,Saratov,Russia |
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Abstract: | The effect of surfactant micelles and the second ligand on the efficiency of energy transfer in the Tb3+–flunixin complex was studied. The fluorescence intensity of the Tb3+–flunixin complex was shown to 100-fold increase in the presence of Tween 80 micelles and the second trioctylphosphine oxide ligand. A procedure for the fluorimetric determination of flunixin in the Flunex drug product (NITA-FARM, Saratov, Russia) was developed. The linearity range of the calibration curve was from 1 × 10–7 to 1 × 10–4 M, r 2 = 0.991, and the limit of detection was 4 × 10–8 M (3σ). |
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