Use of high-performance liquid chromatography coupled with high-resolution mass spectrometry for the identification and quantitative determination of tetrodotoxin in pharmaceuticals |
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| Authors: | V. V. Shalabai V. F. Taranchenko I. V. Rybal’chenko A. V. Aksenov A. M. Antokhin F. M. Semchenko M. S. Krymchak |
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| Affiliation: | 1.FGUP “Scientific Center “Signal”,”,Moscow,Russia;2.27 Scientific Center of the Ministry of Defence of the Russian Federation,Moscow,Russia;3.State Pharmaceutical Plant,Moscow,Russia |
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| Abstract: | A procedure is developed for the identification and determination of tetrodotoxin in pharmaceuticals by liquid chromatography coupled with high resolution mass spectrometry (HPLC?HRMS). The components of a pharmaceutical sample were separated in the gradient elution mode on a HILIC hydrophilic sorbent and detected by HRMS with electrospray ionization in the mode of registration of selected ion transitions. The calibration curve is linear in the range 0.75?1.25 μg/mL with the correlation coefficient > 0.9995. |
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