Oligo- and poly-nucleotides: 50 years of chemical synthesis |
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| Authors: | Reese Colin B |
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| Institution: | Department of Chemistry, King's College London, Strand, London, UK. colin.reese@kcl.ac.uk |
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| Abstract: | It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a dinucleotide with natural 3'-->5'-internucleotide linkages was reported. The main developments in the methodology of oligo- and poly-nucleotide synthesis that have taken place since are described. |
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