| Characterization of Galactosyl-neoglycoalbumin~1 by MALDI-TOF-MS |
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| 引用本文： | Chun CAI1,2,Yong WU1 1West China School of Pharmacy,Sichuan University,Chengdu 610041 2Guangdong Medical College,Zhanjiang 524023. Characterization of Galactosyl-neoglycoalbumin~1 by MALDI-TOF-MS[J]. 中国化学快报, 2005, 16(6) |
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| 作者姓名： | Chun CAI1 2 Yong WU1 1West China School of Pharmacy Sichuan University Chengdu 610041 2Guangdong Medical College Zhanjiang 524023 |
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| 作者单位： | Chun CAI1，2，Yong WU1 1West China School of Pharmacy，Sichuan University，Chengdu 610041 2Guangdong Medical College，Zhanjiang 524023 |
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| 摘 要： | It was reported there was a membrane receptor, hepatic binding protein (HBP), which resides only at the cell surface of mammalian hepatocytes, selectively bind galactose- terminated glycoprotein for transporting to hepatic lysosomes1. According to this discovery, a special analog ligand, galactosyl-neoglycoalbumin(NGA), was prepared as hepatic targeting drug carrier and hepatic screening agents. The ligand was synthesized by covalent coupling of carbohydate bifunctional reagent, 2-imino-2-et…
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Characterization of Galactosyl-neoglycoalbumin1 by MALDI-TOF-MS |
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| Chun CAI,,Yong WU West China School of Pharmacy,Sichuan University,Chengdu Guangdong Medical College,Zhanjiang. Characterization of Galactosyl-neoglycoalbumin1 by MALDI-TOF-MS[J]. Chinese Chemical Letters, 2005, 16(6) |
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| Authors: | Chun CAI Yong WU West China School of Pharmacy Sichuan University Chengdu Guangdong Medical College Zhanjiang |
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| Affiliation: | Chun CAI1,2,Yong WU1 1West China School of Pharmacy,Sichuan University,Chengdu 610041 2Guangdong Medical College,Zhanjiang 524023 |
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| Abstract: | Matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS, model AXIMA CFR+) was used to analyze galactosyl-HSA (human serum albumin) synthesized in our laboratory. It clearly showed that HSA covalently combined with galactoses. Galactosyl-HSA is pure and the ratio of galactosyl residues to protein is 48:1. |
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| Keywords: | Galactose HSA MALDI-TOF-MS protein. |
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