The decarboxylative Strecker reaction |
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Authors: | Das Deepankar Richers Matthew T Ma Longle Seidel Daniel |
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Institution: | Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA. |
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Abstract: | α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry. |
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