Optimization of fermentation conditions for production of glycopeptide antibiotic vancomycin by Amycolatopsis orientalis |
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Authors: | Padma P Naga Rao A Bhaskar Yadav J S Reddy Gopal |
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Institution: | (1) Department of Microbiology, Osmania University, 500 007 Hyderabad, India;(2) Indian Institute of Chemical Technology, 500 007 Hyderabad, India |
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Abstract: | Glycopeptides produced by Streptomyces species are the drugs used against β-lactam drug-resistant staphylococcal infections, and vancomycin is important among them.
Increased prevalence of resistant strains increased the usage of vancomycin worldwide and also promoted attempts for indigenous
production. The optimum process conditions pH, temperature, inoculum size, agitation, and aeration for vancomycin production
by Amycolatopsis orientalis were evaluated, statistically analyzed, and the response surface curves were constructed. The optimum process conditions
were a pH of 7.6, a temperature of 29°C, an inoculum size of 4.5%, an agitation of 255 rpm, and an aeration of less than 1:10
medium-to-air ratio. |
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Keywords: | Fermentation antibiotic glycopeptide vancomycin optimization |
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