Heterocycles [<Emphasis Type="Italic">h</Emphasis>]-fused to 4-oxoquinoline-3-carboxylic acid. Part VII: synthesis of some 6-oxoimidazo[4,5-<Emphasis Type="Italic">h</Emphasis>]quinoline-7-carboxylic acids and esters期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Heterocycles [h]-fused to 4-oxoquinoline-3-carboxylic acid. Part VII: synthesis of some 6-oxoimidazo[4,5-h]quinoline-7-carboxylic acids and esters

Authors:	Maram R. Al-Dweik Jalal A. Zahra Monther A. Khanfar Mustafa M. El-Abadelah Klaus-Peter Zeller Wolfgang Voelter

Affiliation:	1.Chemistry Department, Faculty of Science,University of Jordan,Amman,Jordan;2.Institut für Organische Chemie,Universit?t Tübingen,Tübingen,Germany;3.Interfakult?res Institut für Biochemie,Universit?t Tübingen,Tübingen,Germany

Abstract:	Abstract A series of ethyl 2-(substituted)-9-cyclopropyl-4-fluoro-6-oxo-1H-imidazo[4,5-h]quinoline-7-carboxylates has been prepared from ethyl 7,8-diamino-1,4-dihydroquinoline-3-carboxylate via thermally induced reactions with model alkanoic acids or via microwave-assisted cyclocondensation with some arene carboxaldehydes. Acid-catalysed hydrolysis of the resulting ester derivatives furnished the corresponding imidazoquinoline-7-carboxylic acids. The structures of these new acid and ester derivatives are based on microanalytical and spectral (IR, MS, and NMR) data. Graphical abstract

Keywords:	7,8-Diaminofluoroquinolone Alkanoic acids Arene carboxaldehydes Cyclocondensation Microwave irradiation
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