| Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue |
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| 引用本文： | Hong Xia DING Wei LU Lei Xiang YANG Hai Bo LI Hua BAI Xiu Mei WU Jun Chao CAI Yu ZHAO. Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue[J]. 中国化学快报, 2006, 17(1): 5-8 |
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| 作者姓名： | Hong Xia DING Wei LU Lei Xiang YANG Hai Bo LI Hua BAI Xiu Mei WU Jun Chao CAI Yu ZHAO |
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| 作者单位： | [1]Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031 [2]Shanghai Institute of Material Medica, Chinese Academy of Sciences, SIBS, Shanghai 200031 [3]Zhejiang Hisun Naturelite Pharmaceutical R＆D Co., Ltd., Hangzhou 310007 |
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| 摘 要： | Artabotrine 1 (Figure 1) was isolated from Artabotrys zeylanicus Hook.f. & Thoms., an endemic mainly in Sri Lanka1. The spectral data and single crystal X-ray analysis indicated that artabotrine is a novel and comparatively rare alkaloid characterized with N-methoxylated 4,5-dioxoaporphine, since most of the reported 4,5-dioxoaporphines are N-methylated or no substituted2-11. This highly oxidized aporphine alkaloid was found to possess notable inhibitory activity on P-388 leukemia cell lin…
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| 关 键 词： | 合成 Artabotrine 生物碱 细胞毒性 癌细胞 |
| 收稿时间： | 2005-04-18 |
Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue |
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| Hong Xia DING,Wei LU,Lei Xiang YANG,Hai Bo LI,Hua BAI,Xiu Mei WU,Jun Chao CAI,Yu ZHAO. Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue[J]. Chinese Chemical Letters, 2006, 17(1): 5-8 |
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| Authors: | Hong Xia DING Wei LU Lei Xiang YANG Hai Bo LI Hua BAI Xiu Mei WU Jun Chao CAI Yu ZHAO |
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| Abstract: | Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carded out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines. |
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| Keywords: | Artabotrine aporphine alkaloid cytotoxicity synthesis. |
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