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Paxiphyllines A and B, new alkaloids from Daphniphyllum paxianum
Authors:Yu Zhang   Hongping He   Yingtong Di   Shuzhen Mu   Yuehu Wang   Junsong Wang   Chunshun Li   Ningchuan Kong   Suo Gao  Xiaojiang Hao  
Affiliation:

aState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China

bGraduated School of Chinese Academy of Sciences, Beijing 100039, PR China

cThe Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Science, Guiyang 550002, PR China

dGerman Cancer Research Centre, Pharmaceutical Biology (C015), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

Abstract:Two new Daphniphyllum alkaloids with daphnicyclidin-type skeleton, paxiphyllines A (1) and B (2) were isolated from the twigs and the leaves of Daphniphyllum paxianum. Paxiphylline A (1) has an unprecedented additional carbon from a biogenetic perspective. The structures and relative configurations were elucidated on the basis of spectroscopic data.
Keywords:Daphniphyllum paxianum   Alkaloids   Paxiphylline
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