RM values of some colchicines and colchiceinamides determined by reversed-phase thin-layer chromatography.

The RM values of twelve colchicines and eight colchiceinamides were measured using reversed-phase thin-layer chromatography. The RM values were calculated by extrapolation from the linear range of a plot of RM values versus the composition of the mobile phase. The results showed that in the colchicine series substitution at the nitrogen in position C7 decreases the lipophilicity, whereas in the colchiceinamide series substitution at the nitrogen in position C10 increases lipophilicity. The influence of other substituent groups on the RM values are considered.