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A new laccase-catalyzed domino process and its application to the efficient synthesis of 2-aryl-1H-benzimidazoles |
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| Authors: | Heiko LeutbecherMihaela-Anca Constantin Sabine MikaJürgen Conrad Uwe Beifuss |
| Institution: | Bioorganische Chemie, Institut für Chemie, Universität Hohenheim, Garbenstraße 30, D-70599 Stuttgart, Germany |
| Abstract: | The laccase-catalyzed domino reaction of o-phenylenediamine and benzaldehydes with aerial oxygen as the oxidant exclusively yields 2-aryl-1H-benzimidazoles in good to very good yields. It is easy to perform under very mild reaction conditions. |
| Keywords: | Laccase Aerobic oxidation Domino reactions N-Heterocycles |
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