Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis |
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| Authors: | Joseph A Nielsen Pierre Lau Dragan Maric Jeffery L Barker and Lynn D Hudson |
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| Institution: | (1) Section of Developmental Genetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA;(2) Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA;(3) Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA |
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| Abstract: | Background Cortical development is a complex process that includes sequential generation of neuronal progenitors, which proliferate and
migrate to form the stratified layers of the developing cortex. To identify the individual microRNAs (miRNAs) and mRNAs that
may regulate the genetic network guiding the earliest phase of cortical development, the expression profiles of rat neuronal
progenitors obtained at embryonic day 11 (E11), E12 and E13 were analyzed. |
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