Synthesis and reactivity of imide-derived bisvinyl phosphates. Reactivity of 2,6-disubstituted 1,4-dihydropyridines |
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Authors: | Mousset Deborah Gillaizeau Isabelle Sabatié Andréa Bouyssou Pascal Coudert Gérard |
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Institution: | ICOA, UMR 6005, Université d'Orléans, BP 6759, 45067 Orléans Cedex 2, France. |
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Abstract: | Symmetrical and unsymmetrical 2,6-disubstituted dihydropyridines were prepared in high yields under mild conditions using the Suzuki and Stille Pd-catalyzed coupling reactions of imide-derived bisvinyl phosphates with a range of aryl, heteroaryl, and alkenyl moieties. The alkylation reaction at C-4 easily afforded original tri- and tetrasubstituted dihydropyridines. Hydrolysis of the latter under acidic condition provided efficiently either open-chain 1,5-diketones or di- or trisubstituted pyridines. |
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