Stereoselective synthesis of the phorboxazole A macrolide by ring-closing metathesis |
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| Authors: | Wang Bo Forsyth Craig J |
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| Affiliation: | Department of Chemistry, Institute of Technology, University of Minnesota, 207 Pleasant Street Southeast, Minneapolis, Minnesota 55455, USA. |
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| Abstract: | [Structure: see text] Described is a regio- and stereoselective ring-closing metathesis (RCM) to form the C2-C3 alkene of the macrolide-containing domain of phorboxazole A. This work demonstrates a dramatic effect of reaction solvent on RCM product (E/Z)-selectivity. This process offers an alternative assembly of the macrolide-containing domain of phorboxazole A, one of the most potent anticancer agents known. |
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