A two-component small molecule system for activity-based detection and signal amplification: application to the visual detection of threshold levels of Pd(II) |
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| Authors: | Baker Matthew S Phillips Scott T |
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| Affiliation: | Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. |
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| Abstract: | A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte. |
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