Isolation of Bacillus stearothermophilus constituent that suppresses mouse mixed leukocyte reaction in vitro. |
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| Authors: | Y Kohama N Murayama K Tanaka A Inada T Nakanishi M Itoh X Ying T Mimura |
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| Institution: | Faculty of Pharmaceutical Sciences, Osaka University, Japan. |
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| Abstract: | A novel immunosuppressant, Fr.5-B, has been isolated from the debris of Bacillus stearothermophilus UK563 autolysate. Fr.5-B suppressed mouse mixed leukocyte reaction at doses ranging from 10(-4) to 1 microgram/ml, but not proliferation stimulated by concanavalin A and lipopolysaccharide. |
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