| 肽脱甲酰化酶抑制剂的合成及其抑菌活性 |
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| 引用本文： | 孟丽娟,汤立达,贾炯,徐为人,张大同,张士俊,王平保,冯勇,任戎,王建武. 肽脱甲酰化酶抑制剂的合成及其抑菌活性[J]. 合成化学, 2006, 14(3): 229-233,243 |
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| 作者姓名： | 孟丽娟 汤立达 贾炯 徐为人 张大同 张士俊 王平保 冯勇 任戎 王建武 |
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| 作者单位： | 山东大学,化学与化工学院,山东,济南,250100;山东大学,化学与化工学院,山东,济南,250100;天津药物研究院,天津,300193;天津药物研究院,天津,300193 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 通过对肽脱甲酰化酶抑制剂构效关系的研究,以放线酰胺素为先导化合物,设计并合成了一系列异噁唑类化合物。其结构经1H NMR,IR,MS和元素分析表征。生物活性实验表明,该类化合物对标准肺炎克雷白球菌有显著的抑菌活性。
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| 关 键 词： | 肽脱甲酰化酶 抑制剂 合成 抑菌活性 |
| 文章编号： | 1005-1511（2006）03-0229-05 |
| 收稿时间： | 2005-12-26 |
| 修稿时间： | 2005-12-26 |
Synthesis of Peptide Deformylase Inhibitor and Their Bacteriostasis Activity |
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| MENG Li-juan,TANG Li-da,JIA Jiong,XU Wei-ren,ZHANG Da-tong,ZHANG Shi-jun,WANG Ping-bao,FENG Yong,REN Rong,WANG Jian-wu. Synthesis of Peptide Deformylase Inhibitor and Their Bacteriostasis Activity[J]. Chinese Journal of Synthetic Chemistry, 2006, 14(3): 229-233,243 |
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| Authors: | MENG Li-juan TANG Li-da JIA Jiong XU Wei-ren ZHANG Da-tong ZHANG Shi-jun WANG Ping-bao FENG Yong REN Rong WANG Jian-wu |
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| Affiliation: | 1, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China; 2. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | According to the structure-activity relationship of peptide deformylase inhibitors,a series of hydroxamic acid derivatives containing isoxazole were designed and synthesized based on the structure of actinonin.The structures of compounds were characterized by ~1H NMR,IR,MS and elemental analysis.The preliminary biological test showed that some compounds exhibited bacteriostasis activities. |
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| Keywords: | peptide deformylase inhibitor synthesis bacteriostasis activity |
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