DBU-Mediated Carboxylative Coupling of Primary Amines,Carbon Dioxide and Propargyl Chlorides |
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Authors: | Wen-Zhen Zhang Xiang Ren Xiao-Bing Lu |
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Institution: | State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning 116024, China |
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Abstract: | A carboxylative coupling reaction of various primary amine and 3‐phenyl‐2‐propynyl or 2‐nonynyl chloride in the presence of 8‐diazabicyclo5.4.0]undec‐7‐ene (DBU) using carbon dioxide as carboxylative reagent was presented. This transition‐metal free reaction system shows broad substrate scope and gives a series of propargylcarbamates in moderate to good yield. The obtained N‐alkyl substituted carbamate product can undergo base‐catalyzed intramolecular cyclization reaction to afford functionalized 4‐methylene‐2‐oxazolidinone in good yield. |
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Keywords: | carbon dioxide fixation amines propargylchlorides carboxylative coupling transition-metal free |
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