An expeditious,environment-friendly,and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives |
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| Authors: | Abdelmounaim Safer Mustapha Rahmouni François Carreaux Ludovic Paquin Olivier Lozach Laurent Meijer Jean Pierre Bazureau |
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| Affiliation: | (1) School of Science, University of Greenwich, (Medway Campus), Chatham Maritime, Kent, ME4 4TB, UK;(2) School of Crystallography, Birkbeck College, University of London, Malet Street, London, WC1E7HX, UK;(3) School of Chemistry, University of Manchester, Brunswick Street, Manchester, M13 9PL, UK;(4) Division of Electronic Engineering & Physics, University of Dundee, Dundee, DD1 4HN, UK; |
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| Abstract: | A series of nine 5-arylidenerhodanine derivatives was prepared in good yields and purity without the use of a solvent or catalyst under microwave-assisted condensation with some substituted isatins. All 5-arylidenerhodanines were evaluated as possible inhibitors of the CK1α/β, CDK5/p25, and GSK-3α/β kinases. None of them showed substantive inhibitory activity against these kinases when evaluated at the concentration of 10 μM. |
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