Effects of natural polysaccharide addition on drug release from calcium-induced alginate gel beads |
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Authors: | Murata Yoshifumi Tsumoto Kumiko Kofuji Kyoko Kawashima Susumu |
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Institution: | Faculty of Pharmaceutical Science, Hokuriku University, Japan. |
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Abstract: | Calcium-induced alginate gel beads (Alg-Ca) containing various polysaccharides, including an alginate hydrolysate, were prepared and the drug release profiles were investigated. Hydrocortisone (HC) was gradually released from Alg-Ca into the mimic gastric fluid, while in intestinal fluid, it was quickly released with the dissolution of Alg-Ca. However, with Alg-Ca containing 5% chitin (CT), dissolution of Alg-Ca was not observed, and release of HC showed apparent zero-order kinetics. Furthermore, addition of the alginate hydrolysate altered the HC-release profile for Alg-Ca. |
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