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The first example of trimethylsilyl methylenenitronate reacting with aldehydes under an apparent Mukaiyama nitro-aldol reaction |
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| Authors: | Frank K MacDonaldKarina MM Carneiro Ian R Pottie |
| Institution: | a Department of Chemistry and Physics, Mount Saint Vincent University, Halifax, Nova Scotia, Canada B3M 2J6 b Department of Chemistry, Saint Mary’s University, Halifax, Nova Scotia, Canada B3H 3C3 |
| Abstract: | Trimethylsilyl methylenenitronate reacts with both aliphatic and aromatic aldehydes in the presence of catalytic amounts of scandium(III) triflate to form the Henry reaction products in low (25%) to good yields (77%). This is the first example of this silyl nitronate undergoing a nitro-aldol reaction under an acid environment. |
| Keywords: | Mukaiyama nitro-aldol 1 2-Nitroalcohol Henry reaction Silyl nitronate Scandium triflate |
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