A simple and eco-friendly method for the aminomethylation of 3-substituted oxindoles via three-component Mannich reaction in aqueous media |
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| Authors: | Xiong-Li Liu Xiao-Mei ZhangWei-Cheng Yuan |
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| Affiliation: | a Key Laboratory for Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
b Graduate School of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | A simple and eco-friendly method for the aminomethylation of various 3-substituted oxindoles via three-component Mannich reaction in aqueous media has been established. A variety of oxindoles containing a quaternary carbon center, which comprises an aminomethyl group were obtained smoothly in good yields (up to 93%) with this method. Particularly valuable features, such as employing cheap and readily available formalin as a useful aminomethylation C1 unit and using water as a reaction medium, are embodied in this method. |
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| Keywords: | Oxindole Mannich reaction Formalin Aminomethylation Water mediated reaction |
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