Synthesis of 8-oxoprotoberberines using acid-mediated cyclization or the Heck reaction |
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| Authors: | Anfeng Chen Kun Zhao Hankun Zhang Xianwen Gan Min Lei Lihong Hu |
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| Affiliation: | (1) Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People’s Republic of China; |
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| Abstract: | Abstract A facile method of synthesizing 8-oxoprotoberberines is described from 6-benzoyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbaldehyde via acid-mediated cyclization or from 2-(2-iodophenethyl)isoquinolin-1(2H)-one via the Heck reaction. The present method offers several advantages, such as good yields and a simple procedure. |
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