| 气相色谱／质谱在有机酸尿症临床诊断中的应用 |
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| 引用本文： | 孙琢琏 董振温. 气相色谱／质谱在有机酸尿症临床诊断中的应用[J]. 分析化学, 1991, 19(1): 89-91 |
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| 作者姓名： | 孙琢琏 董振温 |
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| 作者单位： | 大连理工大学化工学院，大连理工大学化工学院，大连理工大学化工学院，大连理工大学化工学院 大连 116024，大连 116024，大连 116024，大连 116024 |
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| 摘 要： |
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| 关 键 词： | 尿样 有机酸 代谢 质谱 气相色谱 |
Applications of Gas Chromatography/Mass Spectrometry in Clinical Diagnosis of Urinary Organic Acid |
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| Sun Zhuolian,Dong Zhenwen,Zhang Qingzhi,Cao Zhongmin. Applications of Gas Chromatography/Mass Spectrometry in Clinical Diagnosis of Urinary Organic Acid[J]. Chinese Journal of Analytical Chemistry, 1991, 19(1): 89-91 |
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| Authors: | Sun Zhuolian Dong Zhenwen Zhang Qingzhi Cao Zhongmin |
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| Affiliation: | Sun Zhuolian~*,Dong Zhenwen,Zhang Qingzhi,Cao Zhongmin |
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| Abstract: | Urine samples of 12 children from 0.4 to 1.4 years old are investigated by means of GC/MS on SE-30 glass capillary column. Urine samples are successively extracted with ethyl acetate and the acid mixtures obtained undergo oximation and trimethylsilyation by a reagent mixture of BSA:TMCS:Pyridine=10:1:1. 36 organic acids are identified, quantification of 17 acids is made by using malonic acid as the internal standard. The urine of a patient who has been affected with renal tubular aciduria is analyzed. The concentration of lactic acid is nearly 14 times as high as that of nermal children. Maybe she also suffers from lactic aciduria. Samples of amniotic fluid of two women in delivery are also studied. |
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| Keywords: | Organic acid Metabolism Mass spectrometry |
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