Modulation of quinpirole-induced compulsive-like behavior in rats by environmental changes: Implications for OCD rituals and for exploration and navigation |
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Authors: | Pazit Zadicario Sharon Ronen David Eilam |
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Affiliation: | (1) Department of Zoology, Tel-Aviv University, Ramat-Aviv, 69978, Israel |
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Abstract: | Background Rats treated chronically with the D2–3 dopamine agonist quinpirole were previously proposed as an animal model of obsessive-compulsive disorder (OCD) since their behavior is based on repeated, compulsive-like persistent traveling between a few places in the open field. The aim of the present study was to determine properties of the physical environment that shape such behavior. For this, quinpirole-treated rats were first exposed to an arena with an array of objects (landmarks) and after the development of compulsive-like behavior, the arena was manipulated by multiplying the number of objects, changing their spacing, relocating object array, or removing the objects. |
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