Radical Couplings as Key Steps for the Preparation of Derivatives of Nonactic Acid |
| |
Authors: | Fran?ois Loiseau Jean-Mary Simone David Carcache Pavel Bobal and Reinhard Neier |
| |
Institution: | (1) Department of Chemistry, University of Neuch?tel, Avenue Bellevaux 51, 2007 Neuch?tel, Switzerland; |
| |
Abstract: | Free radical couplings from furan, as cheap starting material, were studied in view of developing a rapid strategy en route to the synthesis of derivatives of nonactin. The chain containing the alcohol function was introduced in one or two steps
in 86% yield. For the introduction of the second chain with the ester function two different coupling methods were tested.
Starting from the advanced intermediates obtained nonactin derivatives can be prepared by catalytic hydrogenation of the furan
ring. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|