Cross-metathesis assisted by microwave irradiation |
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Authors: | Bargiggia Frédéric C Murray William V |
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Institution: | Johnson & Johnson Pharmaceutical Research and Development L.L.C., 1000 Route 202, P.O. Box 300, Raritan, New Jersey 08869, USA. |
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Abstract: | Microwave irradiation effectively accelerates cross-coupling metathesis reactions between deactivated olefins. Reactions have been carried out with the phosphine-free Hoveyda-Grubbs catalyst and the "second generation Grubbs' catalyst." While there have been reports that a "microwave effect" is observed in various transformations, the accelerations we observe are due to the efficient and rapid heating and increased pressure in the microwave apparatus. |
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