An unsymmetrical approach to the synthesis of bismethylene triphosphate analogues |
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Authors: | Taylor Scott D Mirzaei Farzad Bearne Stephen L |
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Institution: | Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1. s5taylor@sciborg.uwaterloo.ca |
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Abstract: | A protected, unsymmetrical bismethylene triphosphate analogue was prepared by sequential Michaelis-Arbuzov reactions on ethyl bis(halomethyl)phosphinates. This species was monodeprotected at one of the terminal phosphonate groups in high yield. The resulting monodeprotected compound was used to achieve the first syntheses of the bismethylene triphosphate analogues of UTP and CTP. |
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