Efficiency in chemistry: from hydrogen autotransfer to multicomponent catalysis |
| |
Authors: | Francisco Alonso Francisco Foubelo José C González-Gómez Ricardo Martínez Diego J Ramón Paola Riente and Miguel Yus |
| |
Institution: | (1) Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010 Graz, Austria |
| |
Abstract: | A hydrogen autotransfer reaction has been applied to the α-alkylation of ketones, with primary alcohols as the electrophilic component, either under homogeneous (using a Ru complex
as catalyst) or under heterogeneous (using Ni nanoparticles) conditions. This process is both very efficient (concerning atom
economy) and ecologically friendly (water as the only by-product generated). On the other hand, three multicomponent reactions,
namely, the Strecker reaction (without any catalyst), the aza-Sakurai process (catalyzed by ferrite), and the addition of
in situ generated Zn enolates to chiral sulfinylimines (catalyzed by Cu), have proven to be very efficient in the generation
of a diversity of polyfunctionalized molecules. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|