Application of thermal analysis to the study of lipidic prodrug incorporation into nanocarriers |
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Authors: | Jennifer Bourgeois Laure-Anne Pierson Julien Nicolas Muriel Lalanne Patrick Couvreur Karine Andrieux |
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Institution: | 1.Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie,UMR CNRS 8612, Université Paris sud 11,Chatenay-Malabry,France |
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Abstract: | Anti HIV molecules as numerous drugs cannot efficiently penetrate into the brain. Prodrug synthesis and encapsulation into
pegylated nanocarriers have been proposed as an approach for brain delivery. Pegylated polymeric nanoparticles and liposomes
were chosen to incorporate glycerolipidic prodrugs of didanosine. Differential scanning calorimetry experiments were performed
on mixtures of prodrugs and lipids or polymer in order to study their interaction. The optimal incorporation ratios were determined
for each prodrug and compared for both types of nanocarriers. All these results would be used to prepare optimised formulations
of didanosine prodrugs loaded into pegylated nanocarriers for brain drug delivery. |
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