Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi |
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| Authors: | Yamaguchi Keishi Okamoto Naoki Tokuoka Keiji Sugiyama Shigeru Uchiyama Nahoko Matsumura Hiroyoshi Inaka Koji Urade Yoshihiro Inoue Tsuyoshi |
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| Institution: | Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Yamada-Oka 2-1, Suita, Osaka 565-0871, Japan. |
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| Abstract: | Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F(2α) from PGH(2) have been determined in the presence or absence of menadione. The binding motif of menadione, known as one of the inhibitors for TcOYE, should accelerate the structure-based development of novel anti-chagasic drugs that inhibit PGF(2α) production specifically. |
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