Folding and unfolding of an elastinlike oligopeptide: "inverse temperature transition," reentrance, and hydrogen-bond dynamics |
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Authors: | Schreiner Eduard Nicolini Chiara Ludolph Björn Ravindra Revanur Otte Nikolaj Kohlmeyer Axel Rousseau Roger Winter Roland Marx Dominik |
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Affiliation: | Lehrstuhl für Theoretische Chemie, Ruhr-Universit?t Bochum, 44780 Bochum, Germany. |
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Abstract: | The temperature-dependent behavior of a solvated oligopeptide, GVG(VPGVG), is investigated. Spectroscopic measurements, thermodynamic measurements, and molecular dynamics simulations find that this elastinlike octapeptide behaves as a two-state system that undergoes an "inverse temperature" folding transition and reentrant unfolding close to the boiling point of water. A molecular picture of these processes is presented, emphasizing changes in the dynamics of hydrogen bonding at the protein/water interface and peptide backbone librational entropy. |
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