Solanum anguivi Lam. Fruits: Their Potential Effects on Type 2 Diabetes Mellitus |
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| Authors: | Aisha Musaazi Sebunya Nakitto John H Muyonga Yusuf Byenkya Byaruhanga Anika E Wagner |
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| Institution: | 1.Department of Food Technology and Nutrition, School of Food Technology Nutrition and Bioengineering, College of Agricultural and Environmental Sciences, Makerere University, P.O. Box 7062 Kampala, Uganda or (A.M.S.N.); (J.H.M.); (Y.B.B.);2.Institute of Nutritional Sciences, Justus-Liebig University, Wilhelmstrasse 20, 35392 Giessen, Germany |
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| Abstract: | Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder of glucose homeostasis associated with a status of insulin resistance, impaired insulin signaling, β-cell dysfunction, impaired glucose and lipid metabolism, sub-clinical inflammation, and increased oxidative stress. Consuming fruits and vegetables rich in phytochemicals with potential antidiabetic effects may prevent T2DM and/or support a conservative T2DM treatment while being safer and more affordable for people from low-income countries. Solanum anguivi Lam. fruits (SALF) have been suggested to exhibit antidiabetic properties, potentially due to the presence of various phytochemicals, including saponins, phenolics, alkaloids, ascorbic acid, and flavonoids. For the saponin fraction, antidiabetic effects have already been reported. However, it remains unclear whether this is also true for the other phytochemicals present in SALF. This review article covers information on glucose homeostasis, T2DM pathogenesis, and also the potential antidiabetic effects of phytochemicals present in SALF, including their potential mechanisms of action. |
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| Keywords: | type 2 diabetes Solanum anguivi fruits antioxidants pathogenesis of diabetes bioactivity oxidative stress antidiabetic glucose homeostasis |
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