Modeling of cellular pearl chain formation using a double photoconductive layer biochip |
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| Institution: | 1. College of Information Science and Engineering, Northeastern University, Shenyang 110819, China;2. Hebei Instruments and Meters Engineering Technology Research Center, Chengde 067000, China;1. Cantabrian Agricultural Research and Training Centre, CIFA, c/Héroes 2 de Mayo 27, 39600 Muriedas, Cantabria, Spain;2. Aarhus University, Department of Agroecology and Environment, Blichers Allé 20, P.O. Box 50, DK-8830 Tjele, Denmark;3. Centro de Investigaciones Agrarias de Mabegondo, Apdo. 10, 15080 A Coruña, Spain;4. International Centre for Tropical Agriculture, CIAT, Apartado Aéreo 6713 Cali, Colombia;1. EE Dept, COMSATS Institute of Information Technology, Islamabad, Pakistan;2. CAST, COMSATS Institute of Information Technology, Islamabad, Pakistan;3. RAI Dept, National University of Science & Technology (NUST), Islamabad, Pakistan;4. Internetworking Program, FE, Dalhousie University, Halifax, Canada;5. Deanship of e-Transactions and Communication, King Saud University, Saudi Arabia;6. CS Dept, COMSATS Institute of Information Technology, Islamabad, Pakistan |
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| Abstract: | A typical double photoconductive layer biochip focusing biological cells and forming specific pearl chains has been studied theoretically in this paper. It was composed of two photoconductive layers coated on the bottom and top of ITO-based glass. A light pattern was used to create face-to-face virtual electrodes and the resulting oscillatory spatial electric field was employed to induce the motion of polarizable neutral particles. In order to estimate the behaviors of the suspended particles, a numerical model including dielectrophoretic forces, dipole–dipole forces and other forces, was implemented by means of the Monte Carlo method. The results indicated that steady-state chains could be formed in a uniform electric field owing to the dipole moment effect. In a non-uniform electric field created by the use of a light pattern, the positive DEP force created a more focused pattern of chains. The work concerning the numerical simulation indicated that this chip could form fixed-length particle chains in perpendicular alignment to satisfy the structured assembly of tissues in the histological engineering application. |
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| Keywords: | Dielectrophoresis Double photoconductive layers Cellular pearl chain Monte Carlo method |
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