3-(2-methylthiopyridin-3-yl)-3-oxopropionic esters |
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| Authors: | Zubarev A A Zav’yalova V K Shestopalov A M |
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| Institution: | 1.N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
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| Abstract: | A reaction of alkyl bromoacetates with substituted 3-cyano-2-methylthiopyridines in the presence of zinc dust furnishes 3-amino-3-(2-methylthiopyridin-3-yl)propenoic
esters. Their hydrolysis under mild conditions leads to 3-(2-methylthiopyridin-3-yl)-3-oxopropionic esters. The latter were
used in the synthesis of pyridine-substituted pyrazolones. |
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