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| 色满-4-酮并[2,3-b]喹啉酮衍生物的合成 | |
| 引用本文： | 韩光范,王进军,姜贵吉. 色满-4-酮并[2,3-b]喹啉酮衍生物的合成[J]. 有机化学, 2003, 23(9): 1004-1007 |
| 作者姓名： | 韩光范 王进军 姜贵吉 |
| 作者单位： | 1. 华东船舶工业学院材料科学与工程学院,镇江,212003 2. 烟台大学应用化学系,烟台,264005 3. 延边大学化学系,延吉,133002 |
| 摘 要： | 以丙酮和适当的芳香醛以及丙二酸二乙酯为原料，合成出未见报道的5-芳基- 1，3-环已二酮作为合成块。利用Friedlaender合成法与2-氨基-3-甲酰基色满-4- 酮缩合，首次完成色满-4-酮并[2,3-b]喹啉酮新四环系化合物的合成。所合成的化 合物均经~1H NMR,~(13)C NMR，IR光谱和元素分析予以证实。化合物2a的结构也从 色谱-质谱联机分析的质谱数据得到进一步确认。化合物的药理学离体实验表明， 化合物2a具有较强的抑制肿瘤细胞生长的活性。 |
| 关 键 词： | 喹啉酮 P 环己二酮 抗癌药 质子磁共振谱法 碳十三核磁共振谱法 红外分光光度法 元素分析 药理 |
| 修稿时间： | 2003-01-03 |
Synthesis of Chroman-4-ono[2,3-b]quinolinone Derivatives |
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| HAN,Guang-Fan,a WANG,Jin-Jun b JIANG,Gui-Ji c. Synthesis of Chroman-4-ono[2,3-b]quinolinone Derivatives[J]. Chinese Journal of Organic Chemistry, 2003, 23(9): 1004-1007 | |
| Authors: | HAN Guang-Fan a WANG Jin-Jun b JIANG Gui-Ji c |
| Affiliation: | School of Materials Science and Engineering, East China Shipbuilding Institute;Department of Applied Chemistry, Yantai University;Department of Chemistry, Yanbian University |
| Abstract: | New building block 5-aryl-1,3-cyclohexanediones were obtained by reaction of acetone with the appropriate aromatic aldehydes, and sequently with diethyl malonate. 5-Aryl-1,3-cyclohexanedione and 2-amino-3-formyl-4-chromanone were condensed by utilizing Friedlaender synthetic method to obtain the title compounds. Title compounds were a new form of tetracyclic system. The preliminary in vitro pharmacodynamic experiments show that compound 2a possesses a significant inhibition effect on the growth of tumours cell. |
| Keywords: | chroman-4-ono[2 3-b]quinolinone 5-aryl-1 3-cyclihexanedione anticancer activity synthesis |
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