| 鬼臼毒素及其衍生物的单电子还原电位测定 |
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| 引用本文： | 汪世龙,王玫,孙晓宇,张超杰,马秀文,倪亚明,姚思德,王文峰.鬼臼毒素及其衍生物的单电子还原电位测定[J].高等学校化学学报,2000,21(1):66-69. |
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| 作者姓名： | 汪世龙 王玫 孙晓宇 张超杰 马秀文 倪亚明 姚思德 王文峰 |
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| 作者单位： | 1. 同济大学测试中心, 上海 200092;
2. 中国科学院上海原子核研究所辐射化学开放研究实验室, 上海 201800 |
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| 基金项目： | 国家自然科学基金! (批准号 :3970 0 0 2 9)资助 |
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| 摘 要： | 采用脉冲辐解技术,杜醌作参比物,通过改变鬼臼毒素、去甲表鬼臼毒素和VP-16的浓度,控制其阴离子向杜醌电子转移的速度,测得了鬼臼毒素、去甲表鬼臼毒素和VP-16的单电子还原电位分别为-310,-339和-334mV,揭示了鬼臼毒素及其衍生物作为抗肿瘤药物的辐射增敏机理.
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| 关 键 词： | 鬼臼毒素及其衍生物 脉冲辐解 单电子还原电位 |
| 收稿时间： | 1999-03-26 |
Determination of One-electron Reduction Potentials of Podophyllotoxin and Its Derivatives by Pulse Radiolysis |
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| WANG Shi-Long,WANG Mei,SUN Xiao-Yu,ZHANG Chao-Jie,MA Xiu-Wen,NI Ya-Ming,YAO Si-De,WANG Wen-Feng.Determination of One-electron Reduction Potentials of Podophyllotoxin and Its Derivatives by Pulse Radiolysis[J].Chemical Research In Chinese Universities,2000,21(1):66-69. |
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| Authors: | WANG Shi-Long WANG Mei SUN Xiao-Yu ZHANG Chao-Jie MA Xiu-Wen NI Ya-Ming YAO Si-De WANG Wen-Feng |
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| Institution: | 1. Analysis and Research Centre of Tongji University, Shanghai 200092, China;
2. Laboratory of Radiation Chemistry, Shanghai Instituteof Nuclear Research, Academia Sinica, Shanghai 201800, China |
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| Abstract: | One-electron reduction potential is one of the important parameters of radiosensitive compound with a high electron affinity. In this work one-electron reduction potentials of podophyllotoxin and its derivatives were determined by pulse radiolysis using duroquinone as references. The one-electron reduction potentials of podophyllotoxin, 4'-demethylepipodophyllotoxin(DMEP) and etoposide (VP-16) are -310 mV, -339 mV, -334 mV, respectively. |
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| Keywords: | Podophyllotoxin and its derivative Pulse radiolysis One-electron reduction potential |
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