Pulse radiolysis studies of mangiferin: A C-glycosyl xanthone isolated from Mangifera indica |
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| Institution: | 1. Department of Neuroscience, Unit of Functional Pharmacology, Uppsala University BMC, Uppsala SE 75124, Sweden;2. Faculty of Pharmacy, University of Tasmania (UTAS), 7001 Hobart, Australia;3. Departamento de Farmacología, Facultad de Ciencias Químicas, Haya de la Torre y Medina Allende, Ciudad Universitaria, Universidad Nacional de Córdoba, 5016 Córdoba, Argentina;4. Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany;5. Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden;6. Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden;7. Department for Clinical Science, Intervention and Technology, Karolinska Institute, Division of Pediatrics, National Childhood Obesity Centre, Stockholm, Sweden;8. Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA |
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| Abstract: | Pulse radiolysis technique has been employed to study the reaction of different oxidizing and reducing radicals with mangiferin. The reaction of  OH radical showed the formation of transient species absorbing in 380–390 and 470–480 nm region. The reaction with specific one-electron oxidants (N3, CCl3O2) also showed the formation of similar transient absorption bands and is assigned to phenoxyl radicals. The pKa values of the transient species have been determined to be 6.3 and 11.9. One-electron oxidation potential of mangiferin at pH 9 has been found to be 0.62 V vs. NHE. The reaction of eaq? showed the formation of transient species with λmax at 340 nm, which is assigned to the ketyl anion radical formed on addition of eaq? at carbonyl site. Reactions of one-electron oxidised mangiferin radicals with ascorbic acid have also been studied. |
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