Synthesis of 11C labelled methyl esters: transesterification of enol esters versus BF3 catalysed esterification—a comparative study |
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| Institution: | 1. Centre for PET, Austin Health, Austin Campus, Studley Road, Heidelberg, VIC 3084, Australia;2. Department of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia;1. Department of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato, CA, Italy;2. Department of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato, CA, Italy;1. Graduate School of Science and Technology, University of Toyama, Toyama 930-8555, Japan;2. Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan;3. Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan;4. Kampo Research Laboratory, Kracie Pharma Ltd., Takaoka 930-0856, Toyama, Japan;5. Tokyo University of Science, Research Institute for Biomedical Science, Noda, Chiba 278-8510, Japan;6. Graduate School of Innovative Life Science, University of Toyama, 930-8555, Japan;1. WuXi AppTec (Shanghai) Co., Ltd., 288 FuTe Zhong Road, Shanghai 200131, People’s Republic of China;2. Jiangsu Kangyuan Pharmaceutical Co., Ltd., 58 Haichangnan Road, Lianyungang 222001, People’s Republic of China;1. Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA;2. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA;3. Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA;4. Department of Pharmacology, University of Iowa, Iowa City, IA 52242-1109, USA;1. Department of Food Safety and Quality, School of Marine Science, Ningbo University, Ningbo 315211, China;2. Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, 1219 Zhongguan Road, Zhenhai District, Ningbo, Zhejiang, 315201, China;1. Department of Geriatric Gastroenterology, the First Affiliated Hospital to Nanjing Medical University, Nanjing 210029, PR China;2. Department of Respiratory Medicine, the Affiliated Nanjing Children Hospital to Nanjing Medical University, Nanjing 210029, PR China;3. Department of Pharmacy, the First Affiliated Hospital to Nanjing Medical University, Nanjing 210029, PR China;4. Department of Oncology, the First Affiliated Hospital to Nanjing Medical University, Nanjing 210029, PR China |
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| Abstract: | C-11 labelled methyl esters have been synthesized via the transesterification of enol esters in the presence of C-11 methanol and 1,3 dichlorodibutylstannoxane as catalyst. This method leaves functional groups intact and allows access to a wider variety of C-11 labelled methyl esters compared to the BF3 catalysed ester formation, which uses carboxylic acids and C-11 methanol as starting materials. |
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