Catalytic asymmetric Henry reaction |
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| Institution: | 1. Natural Products Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India;2. Department of Chemistry, Dibrugarh University, Dibrugarh 786004, Assam, India;1. Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic;2. Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic;1. Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Bhavnagar 364 002, Gujarat, India;2. Academy of Scientific and Innovative Research (AcSIR), CSIR-CSMCRI, Bhavnagar, Gujarat 364002, India;3. Computation and Simulation Unit (Analytical Discipline and Centralized Instrument Facility), CSIR–Central Salt and Marine Chemicals Research Institute, Bhavnagar 364002, India |
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| Abstract: | The classical Henry reaction, the coupling of a nitroalkane with a carbonyl compound in the presence of a base, is an important C–C bond forming reaction in organic chemistry giving β-nitroalcohols, which are useful synthons in organic synthesis. However, an asymmetric version of the reaction, that has been developed recently, gives a new dimension to the classical Henry reaction whereby the control of stereochemistry of two newly generated carbon centres has become possible. In this review, the various catalytic methods for this purpose are discussed. |
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