Final product analysis in the e-beam and gamma radiolysis of aqueous solutions of metoprolol tartrate |
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| Institution: | 1. Department of Materials Science, Faculty of Science, Kasetsart University, 50 Phahonyothin Road, Ladyao, Chatuchak, Bangkok 10900, Thailand;2. Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki-machi, Takasaki, Gunma 370-1292, Japan;1. University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Zatisi 728/II, 389 25 Vodnany, Czech Republic;2. Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Dept. of Soil Science and Soil Protection, Kamýcká 129, 16521 Prague 6, Czech Republic;1. Univ Lyon, Université Claude Bernard Lyon 1, CNRS, IRCELYON, F-69626, 2 Avenue Albert Einstein, Villeurbanne, France;2. Université Clermont Auvergne, CNRS, Sigma-Clermont, Institut de Chimie de Clermont-Ferrand, F-63178, Aubière, France;1. Catalan Institute for Water Research (ICRA), H2O Building, Scientific and Technological Park of the University of Girona, Emili Grahit 101, E-17003, Girona, Spain;2. IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain;3. Water and Soil Quality Research Group, Department of Environmental Chemistry, (IDAEA-CSIC), Jordi Girona 18-26, E-08034, Barcelona, Spain |
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| Abstract: | The radiostability of metoprolol tartrate aqueous solutions and the influence of the absorbed dose (0–50 kGy), dose rate (e-beam (EB) vs. gamma (γ)) and radioprotectors (pharmaceutical excipients) are investigated by HPLC-UV analyses and through computer simulations. The use of radioprotecting excipients is more promising than an increase in the dose rate to lower the degradation of metoprolol tartrate aqueous solutions for applications such as radiosterilization. The decontamination of metoprolol tartrate from waste waters by EB processing appears highly feasible. |
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