Cyclobutyl-carbonyl substituted PNA: synthesis and study of a novel PNA derivative |
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| Affiliation: | 1. Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain;2. Department of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Blegdamsvej, 3C, DK-2200 Copenhagen, Denmark;1. Department of Chemistry, The University of Texas-Pan American, 1201 W. University Dr., Edinburg, TX 78539, USA;2. Department of Chemistry and Biochemistry, Texas State University, 601 University Dr., San Marcos, TX 78666, USA;3. Department of Chemistry, Ram Sakhi Ram Niwas Shikshan Sankul Bharauli, Gorakhpur-273402, U.P., India;4. Community Health Systems of South Texas, 3135 South Sugar Road, Edinburg, TX 78539, USA;1. Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China;2. School of Chemical Engineering, Xiangtan University, Xiangtan, Hunan 411105, China;1. Chemistry Department, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran;2. Young Researchers Society, Shahid Bahonar University of Kerman, Kerman, Iran;1. Organic Chemistry Process Design, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064-6016, USA;2. Molecular Binding Characterization, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064-6016, USA |
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| Abstract: | A new, optically active, cyclobutyl-carbonyl substituted PNA monomer has been synthesized stereoselectively from a chiral amino acid prepared from (+)-α-pinene. A conformational search shows a lack of conformational bias for the monomer and incorporation of the monomer into a standard oligomer is tolerated without changing the binding affinity towards sequence complementary RNA, DNA or PNA targets. |
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