Synthesis of novel serotonergics and other N-alkylamines using simple reductive amination using catalytic hydrogenation with Pd/C |
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| Authors: | George N KarageorgeJohn E Macor |
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| Institution: | Bristol-Myers Squibb R&D, Neuroscience Discovery Chemistry, 5 Research Parkway, Wallingford, CT 06492, United States |
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| Abstract: | Formation of N-alkylated α-methyltryptamine derivatives (2) was accomplished by simple reductive amination of amine (1) with ketones using catalytic hydrogenation conditions (3 atm H2 and 10% Pd on carbon). This method was also applied to other primary and secondary amines using ketones and aldehydes. |
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| Keywords: | Reductive amination Catalytic hydrogenation Tryptamine derivatives Amine alkylation |
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