Heteroatom‐embedded Medium‐Sized Cycloalkynes: Concise Synthesis,Structural Analysis,and Reactions |
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Authors: | Runyan Ni Naoto Mitsuda Takeru Kashiwagi Kazunobu Igawa Katsuhiko Tomooka |
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Abstract: | A variety of medium‐sized cycloalkynes were efficiently synthesized by the double Nicholas reaction of cobalt complex and bis(hetero)substituted acyclic compound. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Furthermore, preparation of multifunctionalized alkynes was achieved by embedding the cycloalkyne within a peptide chain. |
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Keywords: | Alkine Cycloadditionen Gespannte Molekü le Heterocyclen Peptide |
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