Modular polymer biosensors by solvent immersion imprint lithography |
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Authors: | Jayven S Moore Sotiris S Xantheas Jay W Grate Thomas W Wietsma Enrico Gratton Andreas E Vasdekis |
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Institution: | 1. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington;2. Pacific Northwest National Laboratory, Physical Sciences Division, Richland, Washington;3. Laboratory of Fluorescence Dynamics, Biomedical Engineering Department, University of California, Irvine, California;4. Department of Physics, University of Idaho, Moscow, Idaho |
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Abstract: | We recently demonstrated Solvent Immersion Imprint Lithography (SIIL), a rapid benchtop microsystem prototyping technique, including polymer functionalization, imprinting and bonding. Here, we focus on the realization of planar polymer sensors using SIIL through simple solvent immersion without imprinting. We describe SIIL's impregnation characteristics, including an inherent mechanism that not only achieves practical doping concentrations, but their unexpected 2‐fold enhancement compared to the immersion solution. Subsequently, we developed and characterized optical sensors for detecting molecular O2. To this end, a substantially high dynamic range is reported, including its control through the immersion duration, a manifestation of SIIL's modularity. Overall, SIIL exhibits the potential of improving the operating characteristics of polymer sensors, while significantly accelerating their prototyping, as it requires a few seconds of processing and no need for substrates or dedicated instrumentation. These are critical for O2 sensing as probed by way of example here, as well as any polymer permeable reactant. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016 , 54, 98–103 |
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Keywords: | films gels imaging optics photophysics sensors |
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