| 改进的2-巯基-5-甲氧基咪唑并[4,5-b]吡啶合成法 |
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| 引用本文： | 李梦龙,成健,曹少庭,刘祖亮. 改进的2-巯基-5-甲氧基咪唑并[4,5-b]吡啶合成法[J]. 应用化学, 2010, 27(1): 122-124 |
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| 作者姓名： | 李梦龙 成健 曹少庭 刘祖亮 |
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| 作者单位： | 南京理工大学化工学院,南京,210094 |
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| 摘 要： | 以2,6-二氯吡啶为起始原料,经甲氧基化、硝化、氨基化、还原及成环5步反应得到2-巯基-5-甲氧基咪唑并[4,5-b]吡啶,总收率45.7%。重点比较了2-氯-6-甲氧基吡啶和2,6-二氯吡啶硝化反应条件及收率的差异,讨论了水合肼、NaOH的用量对目标产物收率的影响。用1HNMR、MS和IR测试技术对目标产物结构进行了表征。
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| 关 键 词： | 2-巯基-5-甲氧基咪唑并[4,5-b]吡啶 2-氨基-3-硝基-6-甲氧基吡啶 硝化 还原 |
| 收稿时间： | 2009-01-08 |
| 修稿时间： | 2009-04-16 |
Improved process for the synthesis of 2-mercapto-5-methoxyimidazo[4,5-b]pyridine |
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| LI Meng-Long,CHENG Jian,CAO Shao-Ting,LIU Zu-Liang. Improved process for the synthesis of 2-mercapto-5-methoxyimidazo[4,5-b]pyridine[J]. Chinese Journal of Applied Chemistry, 2010, 27(1): 122-124 |
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| Authors: | LI Meng-Long CHENG Jian CAO Shao-Ting LIU Zu-Liang |
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| Affiliation: | Chemical Engineering School,Nanjing University of Science &; Technology,Nanjing 210094 |
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| Abstract: | 2-Mercapto-5-methoxyimidazo[4,5-b]pyridine was obtained with 2,6-dichloropyridine as the starting material in five steps,including methoxylation,nitration,amination,reduction and cyclization.The overall yield of 2-mercapto-5-methoxyimidazo[4,5-b]pyridine was up to 45.7%.The differences between reaction conditions and yields of nitration of 2-chloro-6-methoxypyridine and 2,6-dichloropyridine were discussed,the effects of the amounts of hydrazine hydrate and the amounts of sodium hydroxide on the yield of the... |
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| Keywords: | mercaptomethoxyimidazo[4 5-b]pyridine aminonitromethoxylpyridine nitration reduction |
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