| 用聚乙二醇简便合成3-取代-1, 2, 3, 4-四氢吡啶并[3, 2-d]嘧啶-2, 4-二酮 |
| |
| 引用本文： | 向凤英,卢翠芬,杨桂春,陈祖兴.用聚乙二醇简便合成3-取代-1, 2, 3, 4-四氢吡啶并[3, 2-d]嘧啶-2, 4-二酮[J].中国化学,2008,26(3):543-546. |
| |
| 作者姓名： | 向凤英 卢翠芬 杨桂春 陈祖兴 |
| |
| 作者单位： | 湖北大学化学化工学院，湖北，武汉 430062 |
| |
| 摘 要： | 用聚乙二醇作为可溶性聚合物载体和相转移催化剂高效简单的合成了1, 2, 3, 4-四氢吡啶并3, 2-d]嘧啶类化合物。该合成路线为聚乙二醇与2, 3-吡啶二酸酐反应生成聚乙二醇支载的单酯1，接着1被转化成相应的聚乙二醇支载的酰基叠氮2，2经Curtius重排，与胺加成并同时关环给出目标产物，其总产率为84%-88%。
|
| 关 键 词： | 聚乙二醇 支载 合成 1 2 3 4-四氢吡啶并[3 2-d]嘧啶类化合物 Curtius反应 |
| 收稿时间： | 2007-5-19 |
| 修稿时间： | 2007-10-20 |
Facile Synthesis of 3‐Substituted‐1,2,3,4‐tetrahydropyrido‐[3,2‐d]pyrimidine‐2,4‐dione on Poly(ethylene glycol) |
| |
| Feng‐Ying XIANG,Cui‐Fen LU,Gui‐Chun YANG,Zu‐Xing CHEN.Facile Synthesis of 3‐Substituted‐1,2,3,4‐tetrahydropyrido‐[3,2‐d]pyrimidine‐2,4‐dione on Poly(ethylene glycol)[J].Chinese Journal of Chemistry,2008,26(3):543-546. |
| |
| Authors: | Feng‐Ying XIANG Cui‐Fen LU Gui‐Chun YANG Zu‐Xing CHEN |
| |
| Institution: | 1. Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education Faculty of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei 430062, China;2. Tel.: 0086‐027‐50865322;3. Fax: 0086‐027‐88663043 |
| |
| Abstract: | An efficient and short route to synthesize pyrido3,2‐d]pyrimidinediones was achieved using poly(ethylene glycol) as a soluble polymeric support and phase transfer catalyst. The poly(ethylene glycol) (PEG) was reacted with 2,3‐pyridinedicarboxylic anhydride to give PEG‐bound ester 1 , which was transformed into corresponding PEG‐bound acyl azide 2 . Then the PEG‐supported acyl azide 2 was rearranged, reacted with a series of amines and spontaneously cycled to give product 5 in 84%–88% overall yields. |
| |
| Keywords: | poly(ethylene glycol) support synthesis 1 2 3 4‐tetrahydropyrido[3 2‐d]pyrimidine‐2 4‐dione Curtius |
|
| 点击此处可从《中国化学》浏览原始摘要信息 |
| 点击此处可从《中国化学》下载免费的PDF全文 |
|
