Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides |
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Authors: | Mario Alfredo García-Carrillo Ángel Guzmán Eduardo Díaz |
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Affiliation: | Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México, Ciudad de México, Mexico |
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Abstract: | A metal free coupling of heteroaromatic N-tosylhydrazones with thiols is presented. A convenient synthetic route to synthesize heteroaryl N-tosylhydrazones is also showed. Valuable thioethers with pyrroles, pyridines, thieno[2,3-b]pyridines, imidazo[1,2-a]pyridines, and 6H-thieno[2,3-b]pyrroles derivatives were synthesized in good yields. This coupling reaction can be carried out in a one-pot fashion and scaled up to the gram scale by using heteroaryl aldehydes, without the need to isolate the N-tosylhydrazone. |
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Keywords: | Heteroaromatic sulfides Diazocompounds Corresponding authors. |
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