An alternative synthetic strategy for (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin and its epimer |
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| Authors: | Venkata Naresh Vema Y Bharathi Kumari Sridhar Musulla Rama Krishnam Raju Addada Srinivasa Rao Alapati |
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| Institution: | 1. GVK Biosciences Private Limited, Medicinal Chemistry Division, 28A, IDA, Nacharam, Hyderabad 500076, Telangana, India;2. Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad 500085, Telangana, India |
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| Abstract: | A concise total synthesis of (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin and its epimer have been synthesized from commercially available (R)-propylene oxide and Orsellinic acid as starting materials. The key steps involved in the synthesis are Wittig reaction, epoxide ring opening with 1,3-dithiane intermediate and Yamaguchi macrolactonization. |
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| Keywords: | Lasiodiplodins Yamaguchi macrolactonization |
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