Synthesis of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones via microwave-assisted base-free intramolecular cross dehydrogenative coupling |
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| Authors: | Chang-Xue Gu Wen-Wen Chen Bin Xu Ming-Hua Xu |
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| Affiliation: | 1. Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China;2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China |
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| Abstract: | A microwave-assisted base-free intramolecular cross dehydrogenative coupling (CDC) of 3-aniline substituted coumarins and quinolinones have been developed. A broad range of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones can be easily afforded in good to high yields (up to 93%) under palladium catalysis. The method is among the most straightforward and convenient ways to access these fused polyheterocycles. |
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| Keywords: | Palladium Cross dehydrogenative coupling Microwave-assisted synthesis Fused polyheterocycles |
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